Allevi Author: Lattices vs Sheets for Cardiac Tissue Bioprinting

There are so many variables that go into creating viable 3d bioprinted tissues; bioink selection, print geometry, cure times, rigidity, flexibility, degradation time and cell viability to name a few. Not to mention, each of these parameters needs to be analyzed and perfected for every cell line in the body. As a community, we are still figuring out the perfect protocol for each organ system.

In a new paper out this week titled “A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures”, our newest Allevi Authors tackled one of these lingering questions, “What is the best print structure for cardiac tissue, lattice or sheet?”

Researchers at University of Texas El Paso and University of Texas at Austin used their Allevi 2 bioprinter and furfuryl gelatin to study and compare 3d bioprinted lattices vs sheets. Through their comparison, they discovered that the lattice structure was more porous with enhanced rheological properties and exhibited a lower degradation rate compared to the rectangular-sheet.

Further, the lattice allowed cells to proliferate to a greater extent compared to the rectangular-sheet. All of these results collectively affirmed that the lattice poses as a superior scaffold design for tissue engineering applications.

Read the full paper here to learn more about the rigorous testing and analysis the team conducted during their study.

Bioprinting offers hope of new treatment paths for cancer patients

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Our amazing users at The University of Waikato will use their Allevi 2 to research new treatment paths for cancer patients that could eventually lead to cancer tumors being treated outside patients' bodies.

We are constantly inspired by this amazing community of scientists who are changing the way we design, heal and build with life. And we're here to support them along the way! Read on to learn more about this incredible research.

Allevi Author: Review of Bone Biofabrication Methods & Bioinks

In the USA alone, 500,000 bone grafting procedures are performed annually, with musculoskeletal-related disabilities costing about $240 billion each year. In spite of the advancements over the past 20 years, scientists and engineers have been unable to provide a material that fulfills every characteristic needed for bone tissue to be physiologically relevant in clinical applications.

In this edition of the #AlleviAuthor series, our very own Director of Bioengineering, Taci Pereira, reviews state of the art bone tissue biofabrication technologies for the Journal of 3D Printing in Medicine.

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Pereira examines the six essential characteristics of bone graft materials; osteoinduction, osteoconduction, osteointegration, biocompatibility, translatability, and growth factor necessity.  

In addition to reviewing bioinks for bone engineering, Pereira examines the different techniques that have emerged within the biofabrication field; 3D bioprinting, selective laser sintering (SLS), electrospinning and stereolithography.

Read on below to learn about the promising methods for bone engineering, where Pereira sees a need for innovation and why she is excited for the future of Hyperelastic Bone.

State of the art biofabrication technologies and materials for bone tissue engineering

 

A Birthday Gift from Us to You: The Allevi Rewards Program

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This month marks our fourth birthday and as we look back on our first four years, we are most grateful for the amazing Allevi community. Without you - our customers and collaborators - we would not have reached the landmarks we have as a company. It is because of your groundbreaking work that we have automated the creation of disease models, published in the best scientific journals, and come closer to our goals of bioprinting organs, stopping animal testing, and ending the organ donor list.

From your feedback and support, we have worked tirelessly to improve our platform to suit your needs by creating more versatile bioprinters, more powerful software, and a range of material offerings that allow you to focus on what really matters.

We look forward to continuing to tackle the world’s biggest challenges with you on our side, and we want to show you how grateful we are for your loyalty and support. This is why we are launching the Allevi Rewards program!

With the Allevi Rewards program, you get rewarded for being a part of this community. When you purchase bioinks and bioprinters, you earn points to use in our shop. In addition, you can get bonus points by participating in surveys, giving testimonials, giving bioprinter referrals, posting pictures using our hashtags, and joining our newsletter. Think of it this way – now every dollar in your budget goes even further with us. You are getting more back so that you can keep pushing your work forward! 

Check out our website for more details on how to become one of our Gold, Platinum, or Elite members. And welcome to the family!

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Allevi Bioprinting in Space

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The physical exploration of space began in the 1950s with the race between the Soviet Union and the United States for who could take those weightless first steps.  Orbiting above earth, astronauts have since made countless discoveries of the galaxy we live in and the science of the stars. On top of the celestial research, space exploration has yielded humanity practical tools that improve our daily lives, such as the GPS in your car, the ear thermometer in your medicine cabinet, and the joystick on your gaming console. Without the constraints of gravity, astronauts are able to study and innovate in a truly novel way.

As we continue to explore deeper into space, astronauts are spending more time in orbit than ever before and need tools that are adaptable and customizable for any given task. This is the ethos behind Made in Space, an organization that focuses on increasing human capability in orbit by bringing 3d printing technology onto the International Space Station (ISS). Accessibility to 3D printing on the ISS has allowed astronauts to print custom plastic tools and parts that are needed to successfully achieve their mission. No need to come back to earth to fetch that tool, you can now print it at zero g.

Here at Allevi, we are driven by the goal of being able to 3D bioprint replacement organs for humans. While we continue to understand the capabilities and constraints of 3d biofabrication here on Earth, the ability to explore cellular function in space could afford us novel discoveries of organ form and function that have never before been studied.

Allevi zeroG bioprinting in space on ISS

In pursuit of this novel research, we have partnered with Made in Space to develop the first bioprinter in space; the Allevi ZeroG. We have designed a compatible extruder that can be outfitted onto Made In Space’s existing Additive Manufacturing Facility on the ISS. The ZeroG bio-extruder will allow scientists on the Allevi platform to simultaneously run experiments both on the ground and in space to observe biological differences that occur with and without gravity.

We are excited to continue to revolutionize how we study biology, not only on the ground but now in space. And perhaps one day, the Allevi ZeroG will aid astronauts in 3D bioprinting replacement organs for deep space travel. We’re excited to participate in this next generation space race.

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