Allevi Joins Johnson&Johnson's JPOD Philadelphia Community

As new applications continue to be developed within the Allevi community, we feel the responsibility to join larger ecosystems that connect us with more engineers, scientists, and physicians that can benefit from the power of Allevi’s solutions. Our first successful relationship with a broader ecosystem has been with VWR. They continue to help us introduce our platform to accelerate science around the world. Adding geometry to biology is becoming a standard to be able to generate accurate representations of the body outside the body. 

At Allevi, we are now ready to begin to understand how to translate our communities’ scientific discoveries into the breakthroughs of tomorrow. To do this we realize that we need to co-create solutions with those at the front lines who are bringing new drugs to market, fighting diseases at the bedside, and producing novel solutions for the healthcare system.

Therefore, we are excited to join the Johnson & Johnson Innovation, JLABS JPOD @ Philadelphia community. We believe access to this ecosystem helps us connect with those who understand how Allevi’s applications can serve the healthcare industry. These interactions will guide our community today and in the future. Together we can target healthcare’s biggest needs by creating more accurate, predictable 3D biology models.

As we continue to collaborate with the Johnson & Johnson Innovation community, we will look forward to receiving mentorship, brainstorming with great minds in the industry, and continuing to grow Allevi. It takes a village to raise a company and we are happy to have the JLABS village help us reach new heights.

Dr. Robert Langer Joins the A-Team

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At Allevi, we believe that the democratization of bioprinting can help millions lead longer and healthier lives. By empowering scientist to make complex, relevant, personalized 3D tissues so many breakthroughs will be achieved within healthcare and humanity. And we are at the heart of catalyzing this change.

We have already seen so much success from our users bringing to life new ideas. They have shown us how patterning cells and biomaterials in new ways can generate scientific results unseen before. For example, Dr. Binatta Joddar from the University of El Paso Texas published how the difference between lattice and rectangular sheet structures matter for cardiac tissue engineering. On that same note, Dr. Parr and Dr. McAlpine from The University of Minnesota published how the specific placement of iPS neuron cells in relation to supporting cells matters to achieve relevant spinal cord tissue engineering. And these are just a few examples out of the multitude of papers being created by Allevi products.

As Allevi’s publication list grows, we are excited to begin to understand how we can translate these relevant scientific results into impactful products for the benefit of patients. However, we understand that to help millions in the future we have to continue learn from those who have helped millions in the past.

Therefore, we are excited to announce Dr. Robert Langer has joined our Scientific Advisory Board to teach us the fundamentals of how he has translated so many breakthroughs to patients and created new industries. Dr. Langer a Professor at MIT, has helped start several biotechnology companies, has licensed or sub-licensed over 350 patents to different companies and runs one of the largest bioengineering research labs in the world. “I’m delighted to be working with Allevi and their excellent team,” stated Dr. Langer.

We will work closely with Dr. Robert Langer as well as our other amazing advisors, Dr. Anthony Atala, Dr. Yu Shrike Zhang, and Dr. Aleksander Skardal to understand the best way to translate breakthroughs in our bioprinting community to begin to directly help patients at the bedside.

Allevi Author: 3D Bioprinting a Spinal Cord

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People often ask us, “what is it that a bioprinter can do really well?”, and we tell them that it’s the ability to print and pattern living cells. Your cells are incredible organisms; they understand the environment around them and communicate with other cells to perform specific organ functions. This is why a bioprinter is such an amazing tool - it empowers you to control the geometry and placement of multiple cell types which allows cells to mimic the environments that they are used to in the body. But some cells are more finicky than others… induced pluripotent stem cells and neural cells for instance are difficult to keep alive and difficult to control.

That’s why this next #AlleviAuthor really blew us away with their new paper titled “3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds” and published in Advanced Functional Materials, wherein they used Allevi bioinks to 3D bioprint a spinal cord using induced pluripotent stem cells and oligodendrocyte progenitor cells (OPCs).

Successfully bioprinting multicellular neural tissue is a huge win for the field of regenerative medicine as it would allow damaged tissue to rebuild functional axonal connections across the central nervous system, essentially healing damaged connections. This technique will hopefully help develop new clinical approaches to treat neurological disease, such as spinal cord injury.

You can access the full paper here to learn more.

Cosmetic Animal Testing is on its Way Out

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The fight to ban animal testing recently scored a major victory when California became the first US state to pass a bill that would ban testing cosmetics on animals.

Companies conduct animal tests to determine the safety of new formulas used in cosmetic products. These tests include skin and eye irritation tests to study allergic reactions and “lethal-dose” testing to determine ingredient toxicity.

But these tests have scientific limitations because humans and animals react differently to certain chemicals. Therefore these tests, that are meant to study the safety of cosmetics before they touch human skin, aren’t even relevant.

Here at Allevi, we believe in the future of personalized cosmetic testing. Our 3D bioprinters allow researchers to customize every aspect of their study - including tissue shape, size, geometry and cell line. Imagine a world where drugs and cosmetics are no longer cruelly tested on animals, but tested on patches of human tissue. But not just any human’s tissue but YOURS because you are different from a rabbit and different from a monkey and even different from your fellow human.

We applaud California for following in the EU, Norway, Israel and India’s footsteps. It’s time we replace these outdated methods; not only because they are cruel to animals but because they are ineffective. Allevi is here to usher in a new era for a cruelty free and scientifically relevant future.

Our New Sterile GelMA is Awesome!

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Gelatin Methacrylate (GelMA) is a popular material in bioprinting due to its mechanical properties and printability. However, the process of methacrylating gelatin and sterile filtering it is time-consuming, cumbersome, and inefficient.

We know how annoying it can be! So after months of testing - we're excited to release our new pre-sterilized and pre-loaded GelMA that is ready to be mixed with your cell suspensions and photo-initiators.

No more filtering. No more lost product. No more measuring. Just add your cells and start printing!

We want you to be the first to give it a try!