3D Bioprinting Replacement Heart Valves

allevi advanced biomatrix collagen aortic pulmonary heart valve bioprint 3d bioprinted

Throwing it back today to show you this heart valve that was 3d bioprinted using the Allevi 2 with collagen from Advanced BioMatrix.

Your heart has four valves (one for each chamber) that are made up of thin flaps of tissue called cusps. These flaps open and close to allow blood to move through the heart while beating.  The cusps attach to an outer ring of tougher tissue called the annulus. The annulus helps the valve maintain proper shape under the normal strains and stresses of a heartbeat. 


It is essential that your valves open and close tightly to ensure proper blood flow through the heart and onto the rest of your body. A diseased or damaged valve can give you an irregular heartbeat and eventually lead to heart failure. More than 5 million Americans are diagnosed with heart valve disease every year.

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Many people can live with valve disease and do not require surgery. However, in some cases, the valve needs to be fixed or replaced. Current methods for replacing a damaged valve included plastic parts or animal tissues.

Allevi users are working towards a future where your #doctor is able to 3d bioprint a custom replacement valve from your own heart cells to reduce the rate of failure and rejection. 3D bioprinting is an amazing design tool that allows you to print custom geometries and tune the rheological properties to provide your cells with the support structure they need to do their job. Just another amazing way our users are changing the future of medicine. #buildwithlife #healwithlife

Allevi Named Fierce15 Class of 2018!


We are so honored to be selected by FierceMedTech as one of their Fierce 15 MedTech Companies of 2018!

What really makes Allevi fierce is our amazing community of users who are using their Allevi bioprinters to revolutionize the way we model disease, test novel drugs, and study the body outside the body.

We're proud to empower Allevi users with the tools that will make tangible impacts on patients' lives. Together, we can change the future of medicine. Thank you, FierceMedTech, for your recognition!

You can read more here.

Self Healing with Synthetic Biology

Today, we wanted to provide some context to spark a discussion on using living organisms as supplements in structures to make them self-healing. There is a piece on self-healing concrete that was harnessing calcium carbonate precipitating bacteria. This could have tremendous applications for repairing roadways and buildings, among other things.

Self healing concrete Allevi

It led us to start thinking about how we can perhaps have other similar applications that could harness the combined powers of 3D printing and synthetic biology in order to make structures that could heal themselves.

Talking to two other MD-PhD students over lunch generated a few thoughts that we wanted to share with you. One was about the use of coral implants to heal bone. This is already in the works! There was talk of introducing organisms that would start growing when exposed to air and could be visualized to highlight micro-cracks in places where structural integrity is important. How can we use similar techniques for diagnostics in humans?

These thoughts raise some interesting talking points: 1) How would the living organisms sustain themselves within these non-living structure? 2) Could they grow out of control? 3) What organisms are appropriate for such applications - what are the ethical dilemmas of using higher organisms, such as jellyfish which are known to have plasticity, in such work? How will the increased proliferation of such organisms impact the balance of our surrounding ecosystem?

There are many other issues surrounding these theories of self-healing and we’d love to hear from you!