tissue engineering

3D Bioprinting Replacement Heart Valves

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Throwing it back today to show you this heart valve that was 3d bioprinted using the Allevi 2 with collagen from Advanced BioMatrix.

Your heart has four valves (one for each chamber) that are made up of thin flaps of tissue called cusps. These flaps open and close to allow blood to move through the heart while beating.  The cusps attach to an outer ring of tougher tissue called the annulus. The annulus helps the valve maintain proper shape under the normal strains and stresses of a heartbeat. 

 
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It is essential that your valves open and close tightly to ensure proper blood flow through the heart and onto the rest of your body. A diseased or damaged valve can give you an irregular heartbeat and eventually lead to heart failure. More than 5 million Americans are diagnosed with heart valve disease every year.

 
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Many people can live with valve disease and do not require surgery. However, in some cases, the valve needs to be fixed or replaced. Current methods for replacing a damaged valve included plastic parts or animal tissues.

Allevi users are working towards a future where your #doctor is able to 3d bioprint a custom replacement valve from your own heart cells to reduce the rate of failure and rejection. 3D bioprinting is an amazing design tool that allows you to print custom geometries and tune the rheological properties to provide your cells with the support structure they need to do their job. Just another amazing way our users are changing the future of medicine. #buildwithlife #healwithlife

Introducing: The Allevi Tissue Layering Bioink Kit

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Your cells are smart. They know the forces around them, what materials they are in, and can even sense the smallest details in a bioink. Have you ever wondered how pure your bioinks are? Do they contain any thickening agents that can negatively affect tissue viability and function? It’s worth a look at the data sheet the next time you consider using a new bioink in lab.

Here at Allevi, we take great strides to source the purest bioinks that are most commonly found in our bodies. The collagens we choose provide unparalleled results that biologists and bioengineers love. There is a challenge in doing this though; pure collagen has historically been a very difficult bioink to work with because it is difficult to pattern. Low concentrations of collagen (like the concentration found in your body) have a very low viscosity, making it hard to control the geometry of the tissue and hindering cell directed proliferation.

We have been working in our lab for over a year trying to crack the code on low concentration collagen bioprinting. So much amazing research has already been conducted with collagen that we wanted to make it easy for you to bring that research to the next level with 3D bioprinting.

We’re proud to announce that we have finally achieved the ability to pattern pure collagen in an automated fashion. With our proprietary CORE™ printhead and our new Tissue Layering Kit, you are now able to print and pattern 3 mg/mL type I collagen or 8 mg/mL type I methacrylated collagen. This is the first time that such low concentrations of pure collagen can be printed, patterned, and layered through 3D bioprinting. We can’t wait to see what you will do with this one!

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Bioprinting in the News: 'Bioprinters Are Churning Out Living Fixes to Broken Spines' By WIRED

Image courtesy of www.wired.com

Image courtesy of www.wired.com

Bioprinters are an essential piece of lab equipment for any scientist, researcher, or doctor that wants to study cells in a relevant way. This is because cells in 3D behave differently than their counterparts studied in a 2D environment; they express more accurate biomarkers and perform more physiologically relevant actions. Bioprinters accelerate the pace of research and allow scientists to find innovative solutions to real world problems.

This awesome article by WIRED profiles a team at UC San Diego that has bioprinted a section of spinal cord that can be custom-fit into a patient’s injury.

It’s awesome to see how bioprinting allows researchers to reliably study the body outside the body. Together, we can change the way we study and treat illness!

Read the full article here.

Announcing Our Newest Bioink Kit - The Allevi Vascularization Kit

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One of the challenges within tissue engineering is creating thick tissues. Why is that? To date it has been challenging to add vascularization to 3D printed tissues. 

Vascularization is our body's highway system. Networks of veins reach each cell to deliver fresh oxygen and nutrients, and remove waste and carbon dioxide. This vascular network is essential for organ function.

The challenge within tissue engineering has been to replicate these networks, but even more so… to design them. We have been limited in our bioprinted tissue's thickness because it has been difficult to create these highways in the lab. ....Until now.

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We are excited to launch the Allevi Vascularization Kit that empowers you to replicate some of the most complex vascular trees in an easy way. It enables you to create cm thick tissues in an automated, standardized fashion and allows your thick tissues to live for weeks.

Vascularization is foundational to begin studying, and replicating the body outside the body in a more accurate way. We are excited to provide you with a cornerstone application within the Allevi platform to help you find solutions to humanity's most difficult problems.

Allevi Now Available Through VWR

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Here at Allevi, we are constantly working to make our bioprinters and bioinks accessible to scientists worldwide.  Our mission is to get Allevi 3D bioprinters into the best research labs where they can accelerate the pace of discovery and push the boundaries of biology. That's why today we're excited to announce that you can now shop Allevi products on the world's leading life science equipment distributor; VWR International. 

Now it’s easier than ever to get an Allevi bioprinter into your lab and begin changing the world. Join us.